AutoGen vs OpenAI Agents SDK

A side-by-side comparison of capabilities, autonomy, integrations, and pricing to help you choose.

Short answer: choose AutoGen if you want microsoft framework for multi-agent conversational ai applications (Supervised agent, free); choose OpenAI Agents SDK if you want lightweight open-source framework for building multi-agent workflows (Supervised agent, free).

AutoGenOpenAI Agents SDK
What it isMicrosoft framework for multi-agent conversational AI applicationsLightweight open-source framework for building multi-agent workflows
Typeframeworkframework
AutonomySupervised agentSupervised agent
Pricingfree · Free (open source)free · Free (open source; pay underlying model usage)
Best fordevelopers, enterprisedevelopers
Deploymentself-hosted, apiself-hosted, api
Modalitiestext, code, apitext, code, voice, api
Modelsmodel-agnostic, gpt, claude, open-sourcemodel-agnostic, gpt
Protocolsfunction-calling, rest-apimcp, function-calling, rest-api
IntegrationsOpenAI, Azure OpenAI, Anthropic, OllamaOpenAI API, MCP servers, Python, JavaScript/TypeScript
Capabilities4 documented4 documented

AutoGen

  • +Strong, well-known abstraction for multi-agent conversation (two-agent and group-chat patterns) from Microsoft Research
  • +v0.4 rewrite brings an asynchronous, event-driven architecture with better observability and control
  • +Open source, model-agnostic, and supports humans as first-class participants in agent conversations
  • -Framework, not a product: autonomy and reliability depend entirely on what the developer builds
  • -Now community-managed and described as in maintenance mode, with the original team's active work continuing under the renamed AG2 project
Full AutoGen profile

OpenAI Agents SDK

  • +Minimal, low-abstraction framework that is quick to learn
  • +Built-in handoffs, guardrails, sessions, and tracing
  • +Provider-agnostic (100+ LLMs) with Python and JS/TS (and voice) SDKs
  • -A framework, not a product: you build, host, and secure the agent yourself
  • -Autonomy and safety depend entirely on how the developer configures it
Full OpenAI Agents SDK profile

Which should you choose?

AutoGen is microsoft framework for multi-agent conversational ai applications, best for developers, enterprise. OpenAI Agents SDK is lightweight open-source framework for building multi-agent workflows, best for developers. The right choice depends on the autonomy level you want, your existing integrations, and your budget, all compared above.